[HTML][HTML] Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected …
H Rabezanahary, F Moukambi, D Palesch, J Clain… - Mucosal …, 2020 - Elsevier
Whereas antiretroviral therapy (ART) suppresses viral replication, ART discontinuation
results in viral rebound, indicating the presence of viral reservoirs (VRs) established within
lymphoid tissues. Herein, by sorting CD4 T-cell subsets from the spleen, mesenteric and
peripheral lymph nodes (LNs) of SIVmac251-infected rhesus macaques (RMs), we
demonstrate that effector memory (TEM) and follicular helper (TFH) CD4+ T cells harbor the
highest frequency of viral DNA and RNA, as well of early R-U5 transcripts in ART-naïve …
results in viral rebound, indicating the presence of viral reservoirs (VRs) established within
lymphoid tissues. Herein, by sorting CD4 T-cell subsets from the spleen, mesenteric and
peripheral lymph nodes (LNs) of SIVmac251-infected rhesus macaques (RMs), we
demonstrate that effector memory (TEM) and follicular helper (TFH) CD4+ T cells harbor the
highest frequency of viral DNA and RNA, as well of early R-U5 transcripts in ART-naïve …
