[HTML][HTML] Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescence
T Liu, FG De Los Santos, Y Zhao, Z Wu… - Journal of Biological …, 2019 - ASBMB
Mutations in the genes encoding telomerase reverse transcriptase (TERT) and telomerase's
RNA components as well as shortened telomeres are risk factors for idiopathic pulmonary
fibrosis, where repetitive injury to the alveolar epithelium is considered a key factor in
pathogenesis. Given the importance of TERT in stem cells, we hypothesized that TERT plays
an important role in epithelial repair and that its deficiency results in exacerbation of fibrosis
by impairing this repair/regenerative process. To evaluate the role of TERT in epithelial cells …
RNA components as well as shortened telomeres are risk factors for idiopathic pulmonary
fibrosis, where repetitive injury to the alveolar epithelium is considered a key factor in
pathogenesis. Given the importance of TERT in stem cells, we hypothesized that TERT plays
an important role in epithelial repair and that its deficiency results in exacerbation of fibrosis
by impairing this repair/regenerative process. To evaluate the role of TERT in epithelial cells …
