Telomere dysfunction in peripheral blood lymphocytes from patients with primary sclerosing cholangitis and inflammatory bowel disease
I Laish, H Katz, A Stein, M Liberman, T Naftali… - Digestive and Liver …, 2015 - Elsevier
Background and aims Primary sclerosing cholangitis and inflammatory bowel disease are
two associated, chronic inflammatory, pre-malignant conditions. We hypothesized that
patients with these disorders may harbour telomere dysfunction as a marker of chromosomal
instability. The aim of our study was to compare parameters of the telomere-telomerase
system in these cohorts. Methods In this prospective study, peripheral blood was withdrawn
from patients with primary sclerosing cholangitis (N= 20), inflammatory bowel disease (N …
two associated, chronic inflammatory, pre-malignant conditions. We hypothesized that
patients with these disorders may harbour telomere dysfunction as a marker of chromosomal
instability. The aim of our study was to compare parameters of the telomere-telomerase
system in these cohorts. Methods In this prospective study, peripheral blood was withdrawn
from patients with primary sclerosing cholangitis (N= 20), inflammatory bowel disease (N …
