Importance To reduce the rising incidence of clinical impairment due to Alzheimer disease, it
is essential to define older adults at highest risk. Widowhood may be an unrecognized factor
contributing to accelerated clinical progression along the Alzheimer disease pathway
among cognitively unimpaired older adults. Objective To determine whether widowhood
status and level of brain β-amyloid (ie, the Alzheimer disease pathologic protein) are
additively or interactively associated with cognitive decline among cognitively unimpaired …