B cells and atherosclerosis
P Srikakulapu, CA McNamara - American Journal of …, 2017 - journals.physiology.org
P Srikakulapu, CA McNamara
American Journal of Physiology-Heart and Circulatory Physiology, 2017•journals.physiology.orgB cells have emerged as important immune cells in cardiovascular disease. Initial studies
have suggested that B cells protect against atherosclerosis development. However,
subsequent studies demonstrating aggravation of atherosclerosis by B-2 cells have shed
light on the subset-dependent effects of B cells. Here, we review the literature that has led to
our current understanding of B cell regulation of atherosclerosis, touching on the importance
of subsets, local regulation, human translation, and therapeutic potential.
have suggested that B cells protect against atherosclerosis development. However,
subsequent studies demonstrating aggravation of atherosclerosis by B-2 cells have shed
light on the subset-dependent effects of B cells. Here, we review the literature that has led to
our current understanding of B cell regulation of atherosclerosis, touching on the importance
of subsets, local regulation, human translation, and therapeutic potential.
B cells have emerged as important immune cells in cardiovascular disease. Initial studies have suggested that B cells protect against atherosclerosis development. However, subsequent studies demonstrating aggravation of atherosclerosis by B-2 cells have shed light on the subset-dependent effects of B cells. Here, we review the literature that has led to our current understanding of B cell regulation of atherosclerosis, touching on the importance of subsets, local regulation, human translation, and therapeutic potential.
American Physiological Society