Interleukin-6 produces neuronal loss in developing cerebellar granule neuron cultures
SM Conroy, V Nguyen, LA Quina… - Journal of …, 2004 - Elsevier
CNS levels of the cytokine interleukin-6 (IL-6) are elevated during CNS injury and disease,
but it is unclear if IL-6 contributes to the pathologic process. Our studies show that in a well-
characterized CNS developmental model system, primary cultures of rodent cerebellar
granule neurons, chronic exposure to IL-6 during neuronal development can result in cell
damage and death in a subpopulation of developing granule neurons. Chronic exposure to
IL-6 also increased the susceptibility of the granule neurons to a toxic insult produced by …
but it is unclear if IL-6 contributes to the pathologic process. Our studies show that in a well-
characterized CNS developmental model system, primary cultures of rodent cerebellar
granule neurons, chronic exposure to IL-6 during neuronal development can result in cell
damage and death in a subpopulation of developing granule neurons. Chronic exposure to
IL-6 also increased the susceptibility of the granule neurons to a toxic insult produced by …
