[HTML][HTML] Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis
Intestinal fibrosis is an excessive proliferation of myofibroblasts and deposition of collagen, a
condition frequently seen in Crohn's disease (CD). The mechanism underlying myofibroblast
hyper-proliferation in CD needs to be better understood. In this report, we found that mTOR
inhibitor rapamycin or mTOR deletion in CX3Cr1+ mononuclear phagocytes inhibits
expression of interleukin (IL)− 23, accompanied by reduced intestinal production of IL-22
and ameliorated fibrosis in the TNBS-induced fibrosis mouse model. This inhibition of IL-23 …
condition frequently seen in Crohn's disease (CD). The mechanism underlying myofibroblast
hyper-proliferation in CD needs to be better understood. In this report, we found that mTOR
inhibitor rapamycin or mTOR deletion in CX3Cr1+ mononuclear phagocytes inhibits
expression of interleukin (IL)− 23, accompanied by reduced intestinal production of IL-22
and ameliorated fibrosis in the TNBS-induced fibrosis mouse model. This inhibition of IL-23 …
