Organ protection by caloric restriction depends on activation of the De novo NAD+ synthesis pathway
MR Späth, KJR Hoyer-Allo, L Seufert… - Journal of the …, 2023 - journals.lww.com
Background Clinical practice lacks strategies to treat AKI. Interestingly, preconditioning by
hypoxia and caloric restriction (CR) is highly protective in rodent AKI models. However, the
underlying molecular mechanisms of this process are unknown. Methods Kynureninase
(KYNU) knockout mice were generated by Clustered Regularly Interspaced Short
Palindromic Repeats (CRISPR) and comparative transcriptome, proteome and metabolite
analyses of murine kidneys pre-and post-ischemia-reperfusion injury in the context of CR or …
hypoxia and caloric restriction (CR) is highly protective in rodent AKI models. However, the
underlying molecular mechanisms of this process are unknown. Methods Kynureninase
(KYNU) knockout mice were generated by Clustered Regularly Interspaced Short
Palindromic Repeats (CRISPR) and comparative transcriptome, proteome and metabolite
analyses of murine kidneys pre-and post-ischemia-reperfusion injury in the context of CR or …