VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR
P Rosenberg - Cell calcium, 2022 - Elsevier
Despite a growing number of successful therapies, heart failure remains the most common
cause of death and disability worldwide. Thus, new and novel therapeutic strategies are
urgently needed. Mitochondria of cardiomyocytes generate ATP that is needed to power
cardiac contraction. Mitochondrial-derived ATP activate myosin ATPase at the sarcomere
and the sarcoplasmic reticular (SR) ATPase Ca 2+ pump, both which intersect with Ca 2+
during contraction. Failure to maintain the relationship between mitochondria and SR can …
cause of death and disability worldwide. Thus, new and novel therapeutic strategies are
urgently needed. Mitochondria of cardiomyocytes generate ATP that is needed to power
cardiac contraction. Mitochondrial-derived ATP activate myosin ATPase at the sarcomere
and the sarcoplasmic reticular (SR) ATPase Ca 2+ pump, both which intersect with Ca 2+
during contraction. Failure to maintain the relationship between mitochondria and SR can …
